Development Of Formulation and Technology of Combined Generic Powder for Oral Solution in Sachets Based on the Quality by Design Approach

Using quality by design approaches (dispersion analysis and random balance method), the formulation technology of powder for oral solution in sachets were developed. It includes paracetamol, ascorbic acid, phenylephrine hydrochloride, pheniramine maleate. The influence 27 excipients from 5 functional groups on 11 attributes was established dispersion analysis. preferred selected using utility function. quantities preferable (7 quantitative factors at three levels) researched method. Their pharmaco-technological parameters physical properties studied. optimal composition established. 9 sequences introducing components analyzed byroll compaction is